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GIP is widely present in multiple regions of the rat brain, including the hippocampus, brainstem, cerebral cortex, and cerebellum [49]
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Across analyses, a recurring contrast is observed between (i) a “reproductive” subtype–often reported as higher LH and SHBG with elevated androgens despite comparatively lower BMI and fasting insulin–and (ii) a “metabolic” subtype, characterized by higher adiposity with higher glucose/insulin measures and lower SHBG (and, in some reports, lower LH) (51)
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