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In practice, this often includes women with obesity (e.g., BMI ≥ 30 kg/m 2 )–or those close to this threshold with clinically meaningful IR and/or metabolic comorbidities such as MASLD or impaired glucose tolerance–who have a defined plan for conception or ART within the next year

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To mitigate these effects, providers often recommend taking oral medications with plenty of water or a small amount of food, unless otherwise directed