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GLP-1 receptor agonists: an updated review of head-to-head clinical studies - PMC
The SURPASS trial series (SURPASS 1-5) and SURMOUNT series provide granular data across diverse populations including patients with cardiovascular disease, chronic kidney disease, and diabetes — making Tirzepatide the more data-rich compound for translational research applications
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Moreover, glucagon treatment in human hepatocytes leads to the downregulation of CYP gene expression, and the underlying mechanism may be driven by the activation of glucagon receptors expressed in the liver
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