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Tirzepatide Is Sufficient (Stay Put) If: You're close to your target weight: If tirzepatide has gotten you 80–90% of the way to your goal, switching drugs mid-course introduces titration disruption and new side effects for a marginal numerical gain

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Identifying patients at heightened risk for clinically meaningful lean mass decline represents an essential step in optimizing long-term metabolic and functional outcomes during pharmacologically induced weight reduction