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Unlike Zepbound, which activates the GIP receptor, MariTide blocks it

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One preclinical study compared the effects of single GIPR or GLP-1R agonism and combined GLP-1R/GIPR agonism in female APOE*3-Leiden.CETP mice fed a Western-type diet, a well-established mouse model for human-like lipoprotein metabolism and atherosclerotic development, for 10 weeks