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RESEARCH DESIGN AND METHODS In this parallel-group, participant- and investigator-blinded, phase 2 trial, 245 individuals with type 2 diabetes and BMI ≥27 kg/m 2 on metformin were randomized to weekly semaglutide (2, 8, or 16 mg s.c.) or placebo for 40 weeks
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Gut microbiota is not only a key player in regulating intestinal permeability, inflammation and neuroinflammation, but also in modulating behavior acting as an endocrine organ and modulating neural pathways through MGB axis as commented below
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