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Several segments in the ECD of GCGR, the stalk between ECD and transmembrane helix 1 (TM1) of GLP-1R (residues 130–135), extracellular loop 1 (ECL1) of GIPR (residues 202–207), and intracellular loop 3 (ICL3) of GLP-1R and GIPR (residues 338–343 and 330–333, respectively) were poorly resolved and not modeled in the structures

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For weight management, be aware that in the UK, GLP-1 medications like Wegovy (semaglutide) and Saxenda (liraglutide) are typically only available through specialist weight management services (tier 3 or 4), with specific BMI thresholds and time-limited treatment courses as per NICE guidance