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FDA approves Foundayo, an oral GLP-1 alternative to Wegovy and Ozempic
The main mechanism underlying this phenomenon is the loss of the suppressive activity of insulin to regulate lipolysis in a metabolic dysregulated visceral adipose tissue, even during times of nutrient excess [17]
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Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)
