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The rate of the eye problem known as nonarteritic anterior ischemic optic neuropathy, or NAION, was 8.9 per cent for those taking semaglutide for type 2 diabetes, compared with 1.8 per cent for patients taking non-GLP-1 diabetes medications, researchers reported in JAMA Ophthalmology

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They also suppress glucagon release from α-cells, reducing hepatic glucose production (Figure 1B)