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Retatrutide has the highest overall adverse event burden, primarily because of the dysesthesia issue

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Dulaglutide’s safety profile is consistent with other GLP-1 receptor agonists, with transient nausea being the most frequently reported adverse event (14.6% incidence).⁵⁵ Dose escalation from 0.75 to 1.5 mg is recommended after at least four weeks, based on individual glycemic control needs [57]