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The anti-apoptotic functions of GIP are largely mediated by the PKA-dependent phosphorylation of CREB, whilst the influence of GLP-1 on apoptosis requires PI3K [101, 104]
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The same process of aging at 4 °C for 40 days was used for stock sterile samples in water that were also dissolved in fresh culture media for assays intended to evaluate the permeability of living cells to semaglutide stored for longer periods of time
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