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Using the wrong diluent, incorrect volume, or inappropriate technique can result in: Loss of potency — the active compound degrades before administration Particulate formation — aggregated peptide particles that may cause injection-site reactions or systemic effects Microbial contamination — particularly when aseptic technique is not followed Inaccurate dosing — leading to either sub-therapeutic or potentially toxic concentrations For licensed peptide medicines, manufacturers provide detailed, validated reconstitution instructions within the Summary of Product Characteristics (SmPC), reviewed and approved by regulators following rigorous stability testing
