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You should contact your GP or healthcare provider if you experience: Lymph nodes that persist for more than 3–4 weeks without improvement, particularly if there is no obvious infection Progressive enlargement of lymph nodes over time Hard, fixed, or non-tender lymph nodes that do not move easily under the skin Lymph nodes larger than 2 cm in diameter Supraclavicular lymphadenopathy (swollen nodes above the collarbone), which requires urgent assessment Multiple areas of lymph node swelling (generalised lymphadenopathy) Accompanying symptoms such as unexplained weight loss (beyond expected weight loss from Saxenda), drenching night sweats, persistent fever, or extreme fatigue Difficulty breathing or swallowing if lymph nodes in the neck are significantly enlarged Immediate medical attention (same-day GP appointment or A&E) is warranted if swollen lymph nodes are accompanied by: Severe difficulty breathing or swallowing Signs of severe infection (high fever, rigors, severe pain) Rapidly progressive swelling Your GP will conduct a thorough clinical assessment, including examination of the lymph nodes and evaluation for signs of infection or other underlying conditions