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The strategy disclosed in several patents involves the preparation of two tripeptides (Boc-d-Phe-Cys(Acm)-Phe-OMe and Z-d-Trp-Lys(Boc)-Thr-OMe) and one dipeptide (H-Cys(Acm)-Thr-OMe or -ol), followed by methyl ester hydrolysis and fragment condensation according to the [3 + 3] + 2 scheme
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