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For instance, in both H9c2 cardiomyoblasts and HepG2 hepatocellular carcinoma cells, liraglutide reduces pyroptosis by upregulating SIRT1 expression, scavenging intracellular reactive oxygen species (ROS), and enhancing mitophagy (Yu et al., 2019)
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Glucagon also influences lipid oxidation, hepatic fat metabolism, amino acid turnover, and energy expenditure
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