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The researchers found that the estimated mean change in hemoglobin A1c (HbA1c) after 40 weeks was −1.8, −1.5, and −0.1 percentage points for cagrilintide-semaglutide 2.4 mg each, 1.0 mg each, and placebo, respectively
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(For more on the role of visceral fat in metabolic disease, see Meto's article on How to Avoid High Visceral Fat.) As GLP-1 therapy reduces fat mass, hsCRP typically falls — reflecting a genuine reduction in inflammatory burden, not merely weight loss
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