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Key findings from published and presented studies include: In a phase 2 obesity trial, higher‑dose retatrutide produced average weight loss of around 22.8–24.2% over 48 weeks in people with obesity.​ In participants with type 2 diabetes, retatrutide achieved substantial weight loss and marked improvements in blood sugar and cardiometabolic markers, though average percentage weight loss was somewhat lower than in non‑diabetic obesity cohorts.​ Early studies also reported significant reductions in liver fat and visceral adipose tissue, with a high proportion of participants with fatty liver disease showing resolution of hepatic steatosis at higher doses.​ These results have led several reviews to describe retatrutide as a potential “game changer” in obesity pharmacotherapy, representing the first GLP‑1/GIP/glucagon triple agonist with robust human data.​ Popular coverage has highlighted phase 3 data suggesting average weight losses approaching 29% of body weight in some cohorts (roughly 71 pounds), which is about double typical results with semaglutide over comparable periods

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Sample collection:Walk-in clinic

A new systematic review published in the journal eClinicalMedicine on Wednesday examined 48 studies that analyzed and predicted the outcomes of people who either had diabetes or were overweight or obese and took popular GLP-1 medications such as liraglutide (under brand names such as Victoza and Saxenda), semaglutide (under brand names such as Ozempic, Wegovy, Rybelsus) and tirzepatide (under brand names like Mounjaro and Zepbound)