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History Scientific interest in NNMT increased substantially during the early 2000s as researchers discovered its involvement in metabolic regulation, cellular methylation processes, and adipose tissue function

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To exclude artifactual alterations by the FITC group, we performed kinetic-binding experiments with unlabeled agonists, in competition with exendin-4-FITC, and defined both association rate constants and residence times 43 with consistent effects (Fig