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2022 Canadian Cardiovascular Society Guideline for Use of GLP-1 Receptor Agonists and SGLT2 Inhibitors for Cardiorenal Risk Reduction in Adults - Canadian Journal of Cardiology

The regain problem The main theory for why the majority of patients regain weight so rapidly when they stop taking medication is because the regions of the brain relating to appetite are still dysregulated, priming the person to overconsume

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Liraglutide lowers body weight set point in DIO rats and its relationship with hypothalamic microglia activation