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considerable interest exists in identifying these glucose-independent renoprotective actions Data from clinical trials suggest that GLP-1R agonists and, to a lesser extent, DPP-4 inhibitors marginally improve surrogate renal end points, plausibly beyond the effects of improved glycaemic control Abstract The gastrointestinal tract — the largest endocrine network in human physiology — orchestrates signals from the external environment to maintain neural and hormonal control of homeostasis

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