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Peripheral GLP-1 Signals Rewire Appetite Circuits Without Entering the Brain Peripheral GLP-1 and GLP-1 receptor agonists, although administered outside the brain, can still influence appetite-control circuits through several routes. They may access
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Referral to a Tier 3 or Tier 4 weight management service may be appropriate in line with NICE guidance on obesity management (see NICE CG189 and subsequent updates)
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