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In addition, exenatide was shown to activate GLP-1R and inhibit the PI3K/AKT pathway to inhibit the growth, migration, and invasion of ovarian cancer cells, and promote cell apoptosis, thereby producing anticancer effects on diabetic patients with ovarian cancer (218)

e.g., benefits in endothelial function and recovery from ischemic damage, preservation of myocardial function, reduction in oxidative stress and inflammation, diuretic effect with increased glucose and sodium excretion, and reduction in blood pressure, as well as reduction in intraglomerular pressure and promotion of natriuresis to counter the progression of kidney diseases in T2D patients [8,10]